Targeting Antigen to Clec9a on Dendritic Cell for Humoral Immunity

Grant number: 1124706 | Funding period: 2017 - 2019

Completed

Abstract

Dendritic cells capture infectious organisms and display them to other immune cells to initiate immunity. The process of capturing organisms requires dendritic cells to express a variety of cell-surface receptors that detect components carried by infectious agents. Here we will examine the efficacy of attaching vaccine components to a targeting agent that binds one of these receptors with the aim of enabling dendritic cells to efficiently kick-start immunity against vaccine components.

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